What does the Literature say?

PRORATA - Bouadma L, et al. “Use of procalcitonin to reduce patients’ exposure to antibiotics in intensive care units.” The Lancet. 2010. 375(9713):463-74

ATN - Palevsky PM, et al. “Intensity of renal support in critically ill patients with acute kidney injury.” The New England Journal of Medicine. 2008. 359(1):7-20.

AKIKI - Gaudry S., et al. “Initiation strategies for renal-replacement therapy in the intensive care unit.” The New England Journal of Medicine. 2016. 375(2):122-133

ARDSNet - Brower RG, et al. “Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome.” The New England Journal of Medicine. 2000. 342(18):1301-1308.

ACURASYS - Papazian L., et al. “Neuromuscular blockers in early acute respiratory distress syndrome.” The New England Journal of Medicine. 2010. 363(12):1107-1116.

PROSEVA - Guerin C, et al. “Prone positioning in severe acute respiratory distress syndrome.” The New England Journal of Medicine. 2013. 368(23):2159-2168.

ROSE - National Heart, Lung, and Blood Institute PETAL Clinical Trials Network. “Early neuromuscular blockade in the acute respiratory distress syndrome.” The New England Journal of Medicine. 2019. 380(21): 1997-2008.

RECOVERY - Horby P, et al. “Dexamethasone in Hospitalized Patients with Covid-19 - Preliminary Report.” The New England Journal of Medicine. 2020. e-pub 2020-07-17:1-11.

Nocturnal Dex - Skrobik Y. "Low-Dose Nocturnal Dexmedetomidine Prevents ICU Delirium. A Randomized, Placebo-controlled Trial." Am J Respir Crit Care Med. 2018. 197(9):1147-1156.

MINDS-USA - Girard TD, et al. "Haloperidol and ziprasidone for treatment of delirium in critical illness." The New England Journal of Medicine. 2018. ePub 2018-10-22:1-12.

PADIS Guidelines - Devlin JW, et al. "Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU." Crit Care Med. 2018 Sep;46(9):e825-e873.

SPICE III - Shehabi Y, et al. "Early Sedation with Dexmedetomidine in Critically Ill Patients". The New England Journal of Medicine. 2019. 380(26):2506-2517.

MENDS2 - Hughes CG, et al. "Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis". New England Journal of Medicine. 2021.

AID-ICU - Andersen-Ranberg NC, et al. "Haloperidol for the Treatment of Delirium in ICU Patients". The New England Journal of Medicine. 2022. Online ahead of print(2022-10-26):1-11.

Leuven Surgical - Van den Berghe G, et al. “Intensive Insulin Therapy in Critically Ill Patients.” The New England Journal of Medicine. 2001. 345(19):1359-1367.

Leuven Medical - Van den Berghe G, et al. “Intensive Insulin Therapy in the medical ICU.” The New England Journal of Medicine. 2006. 354(5): 449-61.

NICE-SUGAR - Finfer S, et al. “Intensive versus conventional glucose control in critically ill patients.” The New England Journal of Medicine. 2009. 360(13):1283-1297.

TGC-Fast Trial - Van den Berghe G, et al. “Tight Blood-Glucose Control without Early Parenteral Nutrition in the ICU.” The New England Journal of Medicine. 2023. 389(13):1180-1190.

SAFE - Finfer S, et al. “A comparison of albumin and saline for fluid resuscitation in the intensive care unit.” The New England Journal of Medicine. 2004. 350(22): 2247-2256.

SALT-ED - Self WH, et al. “Balanced crystalloids versus saline in non critically ill adults.” The New England Journal of Medicine. 2018. 378(10):819-828.

SMART-MED - Semler MW, et al. “Balanced crystalloids versus Saline in Critically Ill Adults.” The New England Journal of Medicine. 2018. 378(9):829-839.

MOPETT - Sharifi M, et al. “Moderate pulmonary embolism treated with thrombolysis.” The American Journal of Cardiology. 2013. 111(2):273-277.

AMPLIFY - Angelou G, et al. “Oral apixaban for the treatment of acute venous thromboembolism.” The New England Journal of Medicine. 2013. 369(9):799-808.

ULTIMA - Kutcher, et al. “Randomized, controlled trial of ultrasound-assisted catheter-directed thrombosis is for acute intermediate-risk pulmonary embolism.” Circulation. AHA. 113.005544. EPUB 2013 Nov 13.

Rivers EGDT - Rivers E, et al. “Early Goal Directed Therapy in the Treatment of Severe Sepsis and Septic Shock.” The New England Journal of Medicine. 2001. 345(19):1368-1377

Annane Trial - Annane D, et al. "Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock". Journal of the American Medical Association. 2002. 288(7):862-871.

CORTICUS - Sprung CL, et al. "Hydrocortisone therapy for patients with septic shock". The New England Journal of Medicine. 2008. 358(2):111-24.

SOAP II - De Backer D, et al. “Comparison of dopamine and norepinephrine in the treatment of shock.” The New England Journal of Medicine. 2010. 362(9):779-89.

ARISE - ARISE and ANZICS writers. “Goal-directed resuscitation for patients with early septic shock.” The New England Journal of Medicine. 2014. 371(16):1496-1506.

ProCESS - Angus DC, et al. “A randomized trial of protocol-based care for early septic shock.” The New England Journal of Medicine. 2014. 370(10):1683-1693.

ProMISe - Mouncey PR, et al. “Trial of early, goal-directed resuscitation for septic shock.” The New England Journal of Medicine. 2015. 372(14):1301-1311

Daily ICU Sedation Holidays - Kress JP, et al. "Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation". The New England Journal of Medicine. 2000. 342(20):1471-1477.